@Pietrau Para makapag-submit ng EOI for a skilled immigrant visa (189, 190, 491) you need a positive skills assessment for 1 of the skills in the skilled occupation list https://immi.homeaffairs.gov.au/work-in-australia/Pages/Skill-occupation-list.aspx
To start, I would suggest that you check the list to see if there is an occupation that is suitable for you given your educational qualifications & work experience. Tapos check the requirements for getting a positive skills assessment.
Kung walang occupation sa list na pwede sa iyo, I guess the option would be to apply for a student visa to study a course that would make you qualified for one of the occupations in the list. Note lang na some occupations require several years of work experience post-qualification to get a positive skills assessment. Meron naman occupations na basta may qualification ka, maski walang work experience ay pwede nang makakuha ng positive skills assessment.
There are 2 kinds of 491 visa, family sponsored & state sponsored. If your occupation is under the MLTSSL list, you can submit an EOI for the family sponsored 491 visa & your brother will need to show proof that he lives & works in a regional area. Yun yung tulong na pwede nya magawa, but you need a positive skills assessment for an occupation in the list before anything else.